Intermediate

4-(4-Methylpiperazin-1-ylmethyl)-3-trifluoromethylaniline

7,8-dihydro-5H-cyclohepta[b]pyridine-5,9(6H)-dione

(6S,9R)-6-(2,3-difluorophenyl)-9-((triisopropylsilyl)oxy)-6,7,8,9-tetrahydro-5H-cyclohepta[b]pyridin-5-one

1-bromo-2,3-difluorobenzene

1,4-bis(diphenylphosphino)butane

triisopropylsilyl trifluoromethanesulfonate

Tri-tert-butylphosphonium tetrafluoroborate

2-Dicyclohexylphosphino-2',6'-diisopropoxy-1,1'-biphenyl

(5R)-5-methyl-1,4-diazepane-1-carboxylate benzyl Hydrochloride (SV01)

1-hydroxy-7-azabenzotriazole

5-Methyl-2-(2H-1,2,3-triazol-2-yl)-benzoic acid (SVS01)

5-Methyl-2-(2H-1,2,3-triazol-2-yl)-benzoic acid (SVS01)

N-Methyl Morpholine

1-Ethyl-3-(3-dimethylaminopropyl)carbodiimide (EDC)

Palladium Hydroxide (20%) on carbon

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